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Kamis, 23 September 2010

Bactesyn vial

Sultamicillin: Ampicillin, sulbactam
Indications
Upper & lower resp tract infections; bacterial pneumonia; UTI & pyelonephritis; intra-abdominal infections; bacterial septicaemia; skin, soft tissue, bone & joint infections, gonococcal infections. Prophylaxis of post-op infection in patients undergoing abdominal or pelvic surgery. Prophylaxis of post-op sepsis in termination of pregnancy or caesarean section.
Dosage
Tab Adult & childn >30 kg 375-750 mg twice daily. Childn <30 kg 25-50 mg/kg/day in 2 divided dose. Uncomplicated gonorrhoea 2.25 g as a single dose + probenecid 1 g concomitantly. Vial Adult 1.5-12 g/day in divided doses every 6-8 hr up to a max of 4 g/day of sulbactam. Childn, infant & neonates 150 mg/kg/day in divided doses every 6-8 hr. Prophylaxis of surgical infections 1.5-3 g upon induction of anesth. May be repeated every 6-8 hr.
Contraindications
Hypersensitivity to penicillins.
Special Precautions
Overgrowth of non-susceptible organisms. Check periodically for organ system dysfunction eg renal, hepatic & haematopoietic system. Neonates.
Adverse Drug Reactions
GI disturbances, rash, itching, drowsiness/sedation, fatigue, malaise & headache.
View ADR Monitoring Form
Pregnancy Category (US FDA)


Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
MIMS Class
Penicillins
ATC Classification
J01CR04 - Sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

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