Climadan Klindamisin
Komposisi :
Tiap kapsul mengandung :
Klindamisin HCI 169,5 mg yang setara dengan Klindamisin base
150 mg
Klindamisin HCI 339 mg yang setara dengan Klindamisin base
300 mg
Tiap 5 ml sirup kering mengandung :
Klindamisin palmitat 120 mg yang setara dengan Klindamisin base
75 mg
Farmakologi:
CLIMADAN merupakan suatu antimikroba dengan spektrum aktivitas yang mirip denqan sensitif entromisin tetap dengan aktivitas lebih besar terhadap organisme yang
CLIMADAN efektif terhadap Streptococcus pyogenes, Streptococcus pneumoniae Streptococcus vindans, H. Influenzae dan Staphylococcus aureus (baik yang sensitif maupun resisten terhadap eritromisin dan penghasil penisilinase) Terhadap anaerob (termasuk B. fragilis) aktivitasnya sebanding dengan metronidazol Percobaan invitro" menunjukkan bahwa CLIMADAN diakumulasikan di sel-sel PM N dan makrofag serta meningkatkan aktivitas P.M.N, sehingga meningkatkan mekanisme pertahanan tubuh.
Sifat-sifat ini mendukung penjelasan mengenai keberhasilan yang baik sekali dari kemanjuran klinisnya untuk infeksi-infeksi yang disebabkan oleh organisme sensitif CLIMADAN diabsorpsi hampir sempurna setelah pemberian oral, dan berbeda denqan entromisin dan linkomisin, absorpsi CLIMADAN tidak dipengaruhi oleh makanan Kadar puncak dalam plasma dicapai dalam 1 jam. Penetrasinya cepat ke dalam jarinqan dan cairan tubuh, tulang maupun nanah. Waktu paruhnya 2,5 jam dan dieliminasi terutama melalui hati.
Indikasi:
- infeksi-infeksi serius yang disebabkan oleh organisme-organisme sensitif seperti infeksi saluran napas atas dan bawah, otitis media, infeksi kulit, osteomielitis endokarditis, infeksi anaerob, serta infeksi-infeksi serius lainnya
- Profilaksis bedah dan pengobatan infeksi pasca bedah yang disebabkan oleh bakteri-bakteri anaerob.
Kontra indikasi:
- Penderita yang hipersensitif terhadap linkomisin dan klindamisin
- Penderita diare, gangguan fungsi hati dan ginjal.
- Atopik individual misalnya : asma dan alergi.
- Tidak diperuntukkan bagi pengobatan terhadap infeksi ringan yang disebabkan oleh bakteri dan virus.
Peringatan dan perhatian :
Keamanan pada wanita hamil dan menyusui belum diketahui dengan pasti Perlu dilakukan pengawasan terhadap kemungkinan timbulnya super infeksi denqan bakteri dan jamur.
Perlu dilakukan pemeriksaan hematologik berkala terutama pada penderita denqan gangguan ginjal dan hati. Hentikan pemakaian antibiotik ini, jika selama pengobatan timbul mencret secara berlebihan. Pada infeksi Streptococcus p haemoliticus hams dilanjutkan paling sedikit 10 hari untuk mengurangi kemungkinan timbulnya demam reumatik atau glomerulonefritis.
Efek samping :
Berupa reaksi hipersensitif: pruritus, rash dan urticaria. Gangguan gastrointestinal antara lain mual, muntah, diare serta kolitis Pemberian secara intravena dosis tinggi dapat menimbulkan flebitis.
Dosis :
Dewasa :
Infeksi serius 150 mg-300 mg tiap 6 jam.
Infeksi yang lebih berat 450 mg tiap 6 jam.
Anak-anak lebih dari 1 bulan :
Infeksi serius 8 mg-16 mg/kg berat badan/hari dalam 3-4 dosis terbagi.
Infeksi yang lebih berat 16 mg-20 mg/kg berat badan/hari dalam 3-4 dosis terbagi.
Kemasan :
Kotak berisi 10 strip x 10 kapsul @ 150 mg.
No. Reg.: DKL8904406001A1
Kotak berisi 5 strip x 10 kapsul @ 300 mg.
No.Reg.: DKL9104406001B1
Botol berisi sirup kering 60 ml.
No.Reg.: DKL8904405937A1
Simpan pada suhu kamar (maks. 30°C).
HARUS DENGAN RESEP DOKTER
Mengenai Saya
- CANGGIH
- Seseorang hanya membutuhkan tiga hal untuk benar-benar bahagia di dunia ini: 1. Orang yang dicintai, 2. Sesuatu yang dicintai, 3. Sesuatu yang diharapkan.
Kamis, 23 September 2010
EMINETON
EMINETON
membantu mengurangi gejala anemia
Komposisi & Informasi nilai gizi :
Takaran saji: 1 tablet (620 mg) Jumlah sajian per kemasan : 100 % AKG
Ferrous Fumarate
90 mg
Cupric Sulfate
0,35 mg
Cobaltous Sulfate
0,15 mg
Manganese Sulfate
0,05 mg
Pyridoxine Hydrochloride
0,192 mg
Cyanocobalamine
5 mCg
AscorbicAcid
60 mg
dl - a - Tocopherol Acetat
5 mg
FolicAcid
400 meg
Calcium Phosphate, Dibasic
60 mg
*AKG berdasarkan pada diet 200 Kcal Farmakologi :
EMINETON adalah tablet yang mengandung zat besi organik (Ferrous Fumarate) dalam dosis terapeutik dengan kombinasi mangan, tembaga, asam askorbat, vitamin B, kalsium, vitamin E dan asam folat, sehingga sangat membantu mempercepat proses pembentukan sel-sel darah. Dapat digunakan untuk menghilangkan gejala anemia dan kurang gizi pada segala tingkat usia.
Indikasi :
Untuk membantu mengurangi gejala anemia karena kekurangan zat besi.
Efek samping :
Pemakaian EMINETON secara berlebihan dapat menyebabkan gangguan gastroenterik seperti diare atau gastritis, mual dan muntah.
Peringatan dan perhatian :
Ada kemungkinan timbul faeces berwarna hitam setelah makan obat ini.
Dosis dan cara pemakaian :
Dewasa : 1 - 2 tablet / hah pada waktu atau sesudah makan.
Anak-anak : 1 tablet / hari pada waktu atau sesudah makan.
Kemasan :
Box berisi 10 strip @ 10 tablet. POM SD 031 505 341
Suplemen makanan.
Simpan pada suhu di bawah 30°C, terlindung dari cahaya.
membantu mengurangi gejala anemia
Komposisi & Informasi nilai gizi :
Takaran saji: 1 tablet (620 mg) Jumlah sajian per kemasan : 100 % AKG
Ferrous Fumarate
90 mg
Cupric Sulfate
0,35 mg
Cobaltous Sulfate
0,15 mg
Manganese Sulfate
0,05 mg
Pyridoxine Hydrochloride
0,192 mg
Cyanocobalamine
5 mCg
AscorbicAcid
60 mg
dl - a - Tocopherol Acetat
5 mg
FolicAcid
400 meg
Calcium Phosphate, Dibasic
60 mg
*AKG berdasarkan pada diet 200 Kcal Farmakologi :
EMINETON adalah tablet yang mengandung zat besi organik (Ferrous Fumarate) dalam dosis terapeutik dengan kombinasi mangan, tembaga, asam askorbat, vitamin B, kalsium, vitamin E dan asam folat, sehingga sangat membantu mempercepat proses pembentukan sel-sel darah. Dapat digunakan untuk menghilangkan gejala anemia dan kurang gizi pada segala tingkat usia.
Indikasi :
Untuk membantu mengurangi gejala anemia karena kekurangan zat besi.
Efek samping :
Pemakaian EMINETON secara berlebihan dapat menyebabkan gangguan gastroenterik seperti diare atau gastritis, mual dan muntah.
Peringatan dan perhatian :
Ada kemungkinan timbul faeces berwarna hitam setelah makan obat ini.
Dosis dan cara pemakaian :
Dewasa : 1 - 2 tablet / hah pada waktu atau sesudah makan.
Anak-anak : 1 tablet / hari pada waktu atau sesudah makan.
Kemasan :
Box berisi 10 strip @ 10 tablet. POM SD 031 505 341
Suplemen makanan.
Simpan pada suhu di bawah 30°C, terlindung dari cahaya.
POSPARGIN
POSPARGIN
GOLONGAN
GENERIK
Metilergometrin maleat.
INDIKASI
Penanganan aktif stadium ke-3 proses kelahiran, atonia (tidak adanya tegangan atau kekuatan otot)/perdarahan rahim, perdarahan dalam masa nifas, subinvolusi (mengecilnya kembali rahim sesudah persalinan hampir seperti bentuk asal), lokiometra (pembendungan getah nifas di dalam rongga rahim).
KONTRA INDIKASI
Wanita hamil, belum terjadi penurunan kepala tetapi persalinan telah memasuki stadium pertama dan kedua, hipertensi berat, toksemia hipertensif, penyakit sumbatan pembuluh darah, sepsis (reaksi umum disertai demam karena kegiatan bakteri, zat-zat yang dihasilkan bakteri, atau kedua-duanya), hipersensitifitas.
Gangguan fungsi hati atau ginjal.
PERHATIAN
Jangan diberikan dalam presentasi abnormal, sebelum proses kelahiran sempurna & pada kehamilan multipel/ganda sebelum anak terakhir dilahirkan, penanganan aktif stadium ke-3 persalinan yang membutuhkan pengawasan dokter kebidanan, suntikan intravena harus diberikan secara perlahan, lebih dari 60 detik.
Hipertensi, gangguan fungsi hati atau ginjal, menyusui.
Interaksi obat : mempertinggi efek vasokonstriktor simpatomimetik atau Ergotamin.
EFEK SAMPING
Nyeri perut, gangguan saluran pencernaan, berkeringat, pusing, sakit kepala, erupsi kulit.
Jarang : hipertensi, bradikardia atau takhikardia, nyeri dada, reaksi vasospastik perifer.
Sangat jarang : reaksi anafilaktik.
KEMASAN
Tablet salut film 0.125 mg x 100 biji.
DOSIS
# Penanganan aktif stadium ke-3 proses kelahiran : 0,1-0,2 mg secara intravena lambat.
# Atonia/perdarahan rahim : 0,2 mg secara intramuskular atau 0,1-0,2 mg secara intravena.
Dapat diulangi dengan jarak waktu 2 jam atau lebih.
# Perdarahan dalam masa nifas, subinvolusi, lokiometra : 0,1-0,2 mg secara subkutan atau intramuskular, sampai dengan 3 kali sehari, pada wanita menyusui : selama 3 hari atau kurang.
GOLONGAN
GENERIK
Metilergometrin maleat.
INDIKASI
Penanganan aktif stadium ke-3 proses kelahiran, atonia (tidak adanya tegangan atau kekuatan otot)/perdarahan rahim, perdarahan dalam masa nifas, subinvolusi (mengecilnya kembali rahim sesudah persalinan hampir seperti bentuk asal), lokiometra (pembendungan getah nifas di dalam rongga rahim).
KONTRA INDIKASI
Wanita hamil, belum terjadi penurunan kepala tetapi persalinan telah memasuki stadium pertama dan kedua, hipertensi berat, toksemia hipertensif, penyakit sumbatan pembuluh darah, sepsis (reaksi umum disertai demam karena kegiatan bakteri, zat-zat yang dihasilkan bakteri, atau kedua-duanya), hipersensitifitas.
Gangguan fungsi hati atau ginjal.
PERHATIAN
Jangan diberikan dalam presentasi abnormal, sebelum proses kelahiran sempurna & pada kehamilan multipel/ganda sebelum anak terakhir dilahirkan, penanganan aktif stadium ke-3 persalinan yang membutuhkan pengawasan dokter kebidanan, suntikan intravena harus diberikan secara perlahan, lebih dari 60 detik.
Hipertensi, gangguan fungsi hati atau ginjal, menyusui.
Interaksi obat : mempertinggi efek vasokonstriktor simpatomimetik atau Ergotamin.
EFEK SAMPING
Nyeri perut, gangguan saluran pencernaan, berkeringat, pusing, sakit kepala, erupsi kulit.
Jarang : hipertensi, bradikardia atau takhikardia, nyeri dada, reaksi vasospastik perifer.
Sangat jarang : reaksi anafilaktik.
KEMASAN
Tablet salut film 0.125 mg x 100 biji.
DOSIS
# Penanganan aktif stadium ke-3 proses kelahiran : 0,1-0,2 mg secara intravena lambat.
# Atonia/perdarahan rahim : 0,2 mg secara intramuskular atau 0,1-0,2 mg secara intravena.
Dapat diulangi dengan jarak waktu 2 jam atau lebih.
# Perdarahan dalam masa nifas, subinvolusi, lokiometra : 0,1-0,2 mg secara subkutan atau intramuskular, sampai dengan 3 kali sehari, pada wanita menyusui : selama 3 hari atau kurang.
PREMASTON
PREMASTON
GOLONGAN
GENERIK
Allylestrenol/Alilestrenol.
INDIKASI
Terancam kelahiran prematur, terancam aborsi, abortus habitualis (keguguran yang berturut-turut pada 3 kehamilan atau lebih).
KONTRA INDIKASI
Kondisi hati abnormal.
PERHATIAN
Diabetes.
EFEK SAMPING
Mual & muntah.
KEMASAN
Tablet 5 mg x 3 x 10 biji.
DOSIS
# Terancam kelahiran prematur : tergantung pada kondisi masing-masing pasien.
Maksimal : 40 mg sehari.
# Terancam aborsi : 3 kali sehari 5 mg selama 5-7 hari.
GOLONGAN
GENERIK
Allylestrenol/Alilestrenol.
INDIKASI
Terancam kelahiran prematur, terancam aborsi, abortus habitualis (keguguran yang berturut-turut pada 3 kehamilan atau lebih).
KONTRA INDIKASI
Kondisi hati abnormal.
PERHATIAN
Diabetes.
EFEK SAMPING
Mual & muntah.
KEMASAN
Tablet 5 mg x 3 x 10 biji.
DOSIS
# Terancam kelahiran prematur : tergantung pada kondisi masing-masing pasien.
Maksimal : 40 mg sehari.
# Terancam aborsi : 3 kali sehari 5 mg selama 5-7 hari.
PROFERTIL
PROFERTIL
Klomifen sitrat 50mg.
INDIKASI
Wanita infertil sebab siklus anovulater dengan amenorea,sindrom stein leventhal,pendarahan rahim fungsional,memperbaiki spermatogenesis pada
pria dengan oligospermia.
KONTRA INDIKASI
Gangguan hati,wanita hamil dan gangguan kandung telur,gangguan pituiari,ovarium dan alat reproduksi lain.
EFEK SAMPING
Dapat menimbulkan ganguan saluran cerna,ruam kulit,hot flushes,diplopia,sakit kepala dan insomnia.
DOSIS
Infertil,anovulater:1-2xsehari 1tablet selama 5 hari,mulai hari ke 5 haid;oligospermia:sehari 1 tablet,selama 7 hari atau lebih.
KEMASAN
Dos 10 tablet.
Klomifen sitrat 50mg.
INDIKASI
Wanita infertil sebab siklus anovulater dengan amenorea,sindrom stein leventhal,pendarahan rahim fungsional,memperbaiki spermatogenesis pada
pria dengan oligospermia.
KONTRA INDIKASI
Gangguan hati,wanita hamil dan gangguan kandung telur,gangguan pituiari,ovarium dan alat reproduksi lain.
EFEK SAMPING
Dapat menimbulkan ganguan saluran cerna,ruam kulit,hot flushes,diplopia,sakit kepala dan insomnia.
DOSIS
Infertil,anovulater:1-2xsehari 1tablet selama 5 hari,mulai hari ke 5 haid;oligospermia:sehari 1 tablet,selama 7 hari atau lebih.
KEMASAN
Dos 10 tablet.
ENDROLIN
Contents
Leuprolide acetate
Indications
Treatment of prostate cancer w/ metastases, endometriosis at genital & extragenital localization.
Dosage
Prostate cancer 1 SC inj renewed every 4 wk. Endometriosis Start treatment during the 1st 5 days of the menstrual cycle. 1 SC or IM inj renewed every 4 wk. Max duration: 6 mth.
Contraindications
Vag bleeding of undetermined origin, pregnancy, lactation.
Special Precautions
Women w/ known risk factors for decreased bone mineral content.
Adverse Drug Reactions
Hypoestrogenism in females & hypotestosteronism in males. Hot flushes, blurred vision, decreased libido, dizziness, edema, headache, nausea, vomiting, breast tenderness, wt gain, cardiac arrhythmias, insomnia, anaphylaxis, paresthesia, syncope.
View ADR Monitoring Form
Pregnancy Category (US FDA)
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
MIMS Class
Hormonal Chemotherapy / Trophic Hormones & Related Synthetic Drugs
ATC Classification
L02AE02 - Leuprorelin ; Belongs to the class of gonadotropin releasing hormone analogues. Used in endocrine therapy.
Drug Classification
G
Presentation/Packing
Form Packing/Price Photo
Endrolin vial
Endrolin 3.75 mg x 1's (Rp1045000)
Leuprolide acetate
Indications
Treatment of prostate cancer w/ metastases, endometriosis at genital & extragenital localization.
Dosage
Prostate cancer 1 SC inj renewed every 4 wk. Endometriosis Start treatment during the 1st 5 days of the menstrual cycle. 1 SC or IM inj renewed every 4 wk. Max duration: 6 mth.
Contraindications
Vag bleeding of undetermined origin, pregnancy, lactation.
Special Precautions
Women w/ known risk factors for decreased bone mineral content.
Adverse Drug Reactions
Hypoestrogenism in females & hypotestosteronism in males. Hot flushes, blurred vision, decreased libido, dizziness, edema, headache, nausea, vomiting, breast tenderness, wt gain, cardiac arrhythmias, insomnia, anaphylaxis, paresthesia, syncope.
View ADR Monitoring Form
Pregnancy Category (US FDA)
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
MIMS Class
Hormonal Chemotherapy / Trophic Hormones & Related Synthetic Drugs
ATC Classification
L02AE02 - Leuprorelin ; Belongs to the class of gonadotropin releasing hormone analogues. Used in endocrine therapy.
Drug Classification
G
Presentation/Packing
Form Packing/Price Photo
Endrolin vial
Endrolin 3.75 mg x 1's (Rp1045000)
Bactesyn vial
Sultamicillin: Ampicillin, sulbactam
Indications
Upper & lower resp tract infections; bacterial pneumonia; UTI & pyelonephritis; intra-abdominal infections; bacterial septicaemia; skin, soft tissue, bone & joint infections, gonococcal infections. Prophylaxis of post-op infection in patients undergoing abdominal or pelvic surgery. Prophylaxis of post-op sepsis in termination of pregnancy or caesarean section.
Dosage
Tab Adult & childn >30 kg 375-750 mg twice daily. Childn <30 kg 25-50 mg/kg/day in 2 divided dose. Uncomplicated gonorrhoea 2.25 g as a single dose + probenecid 1 g concomitantly. Vial Adult 1.5-12 g/day in divided doses every 6-8 hr up to a max of 4 g/day of sulbactam. Childn, infant & neonates 150 mg/kg/day in divided doses every 6-8 hr. Prophylaxis of surgical infections 1.5-3 g upon induction of anesth. May be repeated every 6-8 hr.
Contraindications
Hypersensitivity to penicillins.
Special Precautions
Overgrowth of non-susceptible organisms. Check periodically for organ system dysfunction eg renal, hepatic & haematopoietic system. Neonates.
Adverse Drug Reactions
GI disturbances, rash, itching, drowsiness/sedation, fatigue, malaise & headache.
View ADR Monitoring Form
Pregnancy Category (US FDA)
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
MIMS Class
Penicillins
ATC Classification
J01CR04 - Sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Indications
Upper & lower resp tract infections; bacterial pneumonia; UTI & pyelonephritis; intra-abdominal infections; bacterial septicaemia; skin, soft tissue, bone & joint infections, gonococcal infections. Prophylaxis of post-op infection in patients undergoing abdominal or pelvic surgery. Prophylaxis of post-op sepsis in termination of pregnancy or caesarean section.
Dosage
Tab Adult & childn >30 kg 375-750 mg twice daily. Childn <30 kg 25-50 mg/kg/day in 2 divided dose. Uncomplicated gonorrhoea 2.25 g as a single dose + probenecid 1 g concomitantly. Vial Adult 1.5-12 g/day in divided doses every 6-8 hr up to a max of 4 g/day of sulbactam. Childn, infant & neonates 150 mg/kg/day in divided doses every 6-8 hr. Prophylaxis of surgical infections 1.5-3 g upon induction of anesth. May be repeated every 6-8 hr.
Contraindications
Hypersensitivity to penicillins.
Special Precautions
Overgrowth of non-susceptible organisms. Check periodically for organ system dysfunction eg renal, hepatic & haematopoietic system. Neonates.
Adverse Drug Reactions
GI disturbances, rash, itching, drowsiness/sedation, fatigue, malaise & headache.
View ADR Monitoring Form
Pregnancy Category (US FDA)
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
MIMS Class
Penicillins
ATC Classification
J01CR04 - Sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
CEFSPAN®
CEFSPAN®
Cefixime
Structural Formula
Non-proprietary name: Cefixime.
Chemical name: (5 R, 7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-2-(carboxymethoxyimino)
acetamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo (4.2.0) oct-2-ene-2-carboxylic acid.
Molecular formula: CioH15N507S2; Molecular weight: 453.46
Description: Cefixime is a white to light yellowish crystalline powder, with little or a slight
distinctive odor.
Cefixime is freely soluble in methanol and dimethyl sulfoxide, sparingly soluble in
acetone, slightly soluble in ethanol, and practically insoluble in water, ethyl acetate,
ether and hexane.
Composition
Each capsule contains:
Cefixime.................................................................50 mg (potency) or 100 mg (potency).
Each teaspoon (5 ml) of suspension contains:
Cefixime.................................................................................................100 mg (potency).
Each film coated tablet contains:
Cefixime.............................................................................................200 mg (potency).
Pharmacology Antibacterial activity
Cefixime has broad-spectrum activity against gram-positive and negative microorganisms. In particular, in comparison with the other oral cephalosporins, it has potent activity against such gram-positive organisms as Streptococcus sp., Streptococcuspneumoniae, and such gram-negatives as Branhamella catarrhalis, Escherichia coli, Proteus sp., Haemophillus influenzae, Neisseria gonorrhoeae. Its mode of action is bactericidal. It is extremely stable to p-lactamase produced by many organisms, and has good activity against p-lactamase producing organism.
Mode of action
Its mode of action is inhibition of cell wall synthesis. It has high affinity for penicillin binding proteins (PBP) 1 (1 a, 1 b and 1 c) and 3, with the site of activity varying according to organism.
Pharmacokinetics Serum concentration
Following a single oral dose of 50, 100 or 200 mg (potency) of Cefixime in healthy, fasted adults, maximum serum concentrations at 4 hours were, respectively, 0.69, 1.13 and 1.95 pg/ml. The serum half-life was 2.3 - 2.5 hours.
Following a single oral dose of 1.5, 3.0 or 6.0 mg (potency)/kg of Cefixime in pediatric patients with normal renal function, maximum serum concentrations at 3 - 4 hours were,
respectively, 1.14, 2.01 and 3.97 ug/ml. The serum half-life was 3.2 - 3.7 hours.
Tissue penetration (distribution)
Penetration into sputum, tonsiis, maxillary sinus mucosal tissue, otorrhea, biliary fluid and gall-bladder tissue is good.
Metabolism
No antibacterially active metabolites are found in the human serum or urine.
Excretion
Cefixime is excreted primarily renally. The extent of urinary excretion (up to 12 hours) after oral administration of 50, 100 or 200 mg (potency) in healthy, fasted adults was about 20-25%. Maximum urine concentrations were, respectively, 42.9, 62.2 and 82.7 pg/ml at 4-6 hours. The extent of urinary excretion (up to 12 hours) after oral administration of 1.5, 3.0 or 6.0 mg (potency)/kg in pediatric patients with normal renal function was about 13-20%.
Indications
Cefixime is indicated in the treatment of the following infections when caused by
susceptible strains of the designated microorganisms:
Uncomplicated Urinary Tract Infections caused by Escherichia coli and Proteus mirabilis.
Otitis media caused by Haemophillus influenzae (Beta-lactamase positive and negative strains), Moraxella (Branhamella) catarrhalis (most of which are beta-lactamase positive), and Streptococcus pyogenes.
Pharyngitis and Tonsillitis, caused by Streptococcus pyogenes. Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis, caused by Streptococcus pneumoniae and Haemophillus influenzae (beta-lactamase positive and negative strains).
Treatment of typhoid fever in children, with multi-resistant to the standard drug regiments.
Uncomplicated gonorrhoeae (cervical/urethral) which caused by Neisseria gonorrhoeae (penicilinase-and non penicilinase-producing strains).
Contraindications
Patients with a history of shock or hypersensitivity caused by any ingredient of this product.
Precautions
1. General Precautions: Careful inquiry about any form of hypersensitivity should be made, since reactions such as shock may occur.
2. This product should not be administered to the following patients as a general rule. If necessary, however, it can be administered with care.
Patients with a past history of hypersensitivity to any of ingredients in this product or any other cephem antibiotics.
3. Careful Administration:
a. Patients with a history of hypersensitivity to penicilins.
b. Patients with a personal or familial history of some form of allergy such as bronchial asthma, rash, urticaria.
c. Patients with serious renal functions disorder.
d. Patients with poor oral nutrition, patients receiving parenteral nutrition, elderly patients or patients in a debilitated state; Careful observation is essential
in these patients as vitamin K deficiency symptoms may develop.
4. Use during Pregnancy
Safety during pregnancy has not been established. This product should be administered to pregnant patients or women suspected of being pregnant, only if the expected therapeutic benefit is thought to outweigh any possible risk.
5. Use in Nursing Mother
It is not known whether Cefixime is excreted in human milk. Consideration should be given to discontinuing nursing temporarily during treatment with this drug.
6. Use in Newborns or Prematures
Efficacy and safety in children aged less than 6 months have not been established (including in newborn and prematures).
Adverse Reactions
1. Shock
Adequate caution in administration should be used as shock symptoms may rarely S, h3"y'e d !lgnS 0r sVmPtoms s"ch as feeling unwell, oral cavity discomfort, strrctor dizziness abnormal urge to defecate, tinnitus or diaphoresis occur, this product must be discontinued immediately.
2. Hypersensitivity
If signs of hypersensitivity reactions such as rash, urticaria, erythema, pruritus or Le taken ' be discontinued and appropriate measures should
3. Hematologic
Granulocytopenia or eosinophilia infrequently may occur. Rarely thrombocytopenia SnL S ! Pr°dUCti?h0uld be disc°"tinued if any of these abnormalities is found. It has been reported that hemolytic anemia has occurred with other oephems.
4. Hepatic
Infrequently an increase in GOT, GPT or alkaline phosphatase may occur.
5. Renal
Periodic monitoring of renal function is recommended as serious renal impairment
?™?nrfa h£ ,•rena.' lnsufiSency may rareli'occur-lf anV °f »ese abnormalities is found, discontinuation of this product and other appropriate measures should be
6. Digestive
In rare instances a serious colitis, such as pseudomembranous colitis, manifested by blood in stools, may occur. Abdominal pain or frequent diarrhoea requires appropriate measures including prompt withdrawal of this product infrequently vomiting diarrhoea, abdominal pain, stomach discomfort, heartburn or anorexia and rarely nausea, feeling of enlarged abdomen or constipation may occur!
7. Respiratory
In rare instances, interstitial pneumoniae or PIE syndrome, manifested by fever cough, dyspnea, abnormal chest x-ray or eosinophilia, may occur. If any such' symptoms occur this product should be immediately discontinued and appropriate measures such as giving adrenocortical hormones should be taken.
8. Alteration in bacterial flora
Rarely stomatitis or candidiasis may occur.
9 Vitamin deficiencies
Rarely vitamin K deficiencies (such as hypothrombinemia or bleeding tendencies) ma rT 9r°JP deflclsncles (such as Qlossitis, stomatitis, anorexia or neuritis)
10. Others
• Rarely headache or dizziness may occur.
. In studies where infants rats were given 1.000 mg/kg/day orally, a reduced spermatogenesis was reported. '
11. Influences on laboratory values
a. False-positive results may occur with urine sugar tests using Benedict's solution Testa lS S° and C"niteSt' Fa'Se positives nave not been ^Ported with
b. A positive direct Coombs test may occur.
Dosage and Administration
' weLSWnnt°^le,h 5° T°° mg and tablet 200 m9: For adults and children weighing > 30 kg, he usual recommended daily dose is 50-100 mg (potency) of cefixime given orally twice daily. Dosage should be adjusted according to the age body weight and condition of the patient. For more severe or intractable infections rS.™ I99 may' '"creased JP t0 200 mg (potency) given twice daily.
■ Cefspan® suspension 100 mg: The usual pediatric daily dose is 1.5 - 3 mg (potency)Ao given orally twice daily. Dosage should be adjusted according to the condition of the
ton ™ fr?„rtm°rewfV8re °r int'ac,able infections, the dosage may be increased up to 6 mg (potency)/kg given orally twice daily . I" children, otitis media should be treated with suspension. Clinical studies of otitis medtewera-oondi^ad with the suspension and the suspension results in higher peak blood levels than the tablet when administered at the same dose Therefore S„™l0n sh°u!d not be substituted in the treatment of otitis media!
• Typhoid fever in children: 10 -15 mg/kg/day for 2 weeks
' th.'^ Withrimpaired r9nral ,unction re<'uire modification of dosage depending on he degree of impairment. The recommended dosage is 75% of the standard dosage n»«;n( 9 VJ 1" creatlnine clearance is between 21 and 60 ml/min or for patients on renal hemodialysis, and 50% of the standard dosage (i.e. 200 mg daily)
^huif, me dearan?e is lsss than 20 ml/min or for patients on continuous ambulatory peritoneal dialysis.
• In case of over dosage:
Sfrl™ 'aVa?e m^,be indicated; otherwise, no specific antidote exists. Cefixime is diatyS '" S'gnlflCant 1uantlties from the circulation by hemodialysis or peritoneal
• For uncomplicated cervical/urethral gonorrhoeae, a single dose of 400 mg is recommended. M
Presentation
naS!,Smg: Box of 3 strips x 10 capsules Reg. No. DKL9211616501A1
S Inn m° : n™ ° ? S'ripS X 1 ° CapSUleS Re9- N0- DKL 9211616501B1
Filcotab 200 mg : Box of 1 strip x 10 tablets Reg. No. DKL 0311636517A1
Dry Syrup : Bottle of 30 ml Reg. No. DKL9211616738A1
nrlZC°"fitM°?' *e s,u„sPension maV be kePt 'or 7 days either at room temperature SlSaSvC S'9nifiCant '0SS °' P°,enCy- Keep «gh«V ciosedPDiscard Add 20 ml of water, shake for 60 seconds m
Q Capsules : Store below 25°C. Dry Syrup and Tablet: Store below 30°C.
HARUS DENGAN RESEP DOKTER On medical prescription only.
Cefixime
Structural Formula
Non-proprietary name: Cefixime.
Chemical name: (5 R, 7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-2-(carboxymethoxyimino)
acetamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo (4.2.0) oct-2-ene-2-carboxylic acid.
Molecular formula: CioH15N507S2; Molecular weight: 453.46
Description: Cefixime is a white to light yellowish crystalline powder, with little or a slight
distinctive odor.
Cefixime is freely soluble in methanol and dimethyl sulfoxide, sparingly soluble in
acetone, slightly soluble in ethanol, and practically insoluble in water, ethyl acetate,
ether and hexane.
Composition
Each capsule contains:
Cefixime.................................................................50 mg (potency) or 100 mg (potency).
Each teaspoon (5 ml) of suspension contains:
Cefixime.................................................................................................100 mg (potency).
Each film coated tablet contains:
Cefixime.............................................................................................200 mg (potency).
Pharmacology Antibacterial activity
Cefixime has broad-spectrum activity against gram-positive and negative microorganisms. In particular, in comparison with the other oral cephalosporins, it has potent activity against such gram-positive organisms as Streptococcus sp., Streptococcuspneumoniae, and such gram-negatives as Branhamella catarrhalis, Escherichia coli, Proteus sp., Haemophillus influenzae, Neisseria gonorrhoeae. Its mode of action is bactericidal. It is extremely stable to p-lactamase produced by many organisms, and has good activity against p-lactamase producing organism.
Mode of action
Its mode of action is inhibition of cell wall synthesis. It has high affinity for penicillin binding proteins (PBP) 1 (1 a, 1 b and 1 c) and 3, with the site of activity varying according to organism.
Pharmacokinetics Serum concentration
Following a single oral dose of 50, 100 or 200 mg (potency) of Cefixime in healthy, fasted adults, maximum serum concentrations at 4 hours were, respectively, 0.69, 1.13 and 1.95 pg/ml. The serum half-life was 2.3 - 2.5 hours.
Following a single oral dose of 1.5, 3.0 or 6.0 mg (potency)/kg of Cefixime in pediatric patients with normal renal function, maximum serum concentrations at 3 - 4 hours were,
respectively, 1.14, 2.01 and 3.97 ug/ml. The serum half-life was 3.2 - 3.7 hours.
Tissue penetration (distribution)
Penetration into sputum, tonsiis, maxillary sinus mucosal tissue, otorrhea, biliary fluid and gall-bladder tissue is good.
Metabolism
No antibacterially active metabolites are found in the human serum or urine.
Excretion
Cefixime is excreted primarily renally. The extent of urinary excretion (up to 12 hours) after oral administration of 50, 100 or 200 mg (potency) in healthy, fasted adults was about 20-25%. Maximum urine concentrations were, respectively, 42.9, 62.2 and 82.7 pg/ml at 4-6 hours. The extent of urinary excretion (up to 12 hours) after oral administration of 1.5, 3.0 or 6.0 mg (potency)/kg in pediatric patients with normal renal function was about 13-20%.
Indications
Cefixime is indicated in the treatment of the following infections when caused by
susceptible strains of the designated microorganisms:
Uncomplicated Urinary Tract Infections caused by Escherichia coli and Proteus mirabilis.
Otitis media caused by Haemophillus influenzae (Beta-lactamase positive and negative strains), Moraxella (Branhamella) catarrhalis (most of which are beta-lactamase positive), and Streptococcus pyogenes.
Pharyngitis and Tonsillitis, caused by Streptococcus pyogenes. Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis, caused by Streptococcus pneumoniae and Haemophillus influenzae (beta-lactamase positive and negative strains).
Treatment of typhoid fever in children, with multi-resistant to the standard drug regiments.
Uncomplicated gonorrhoeae (cervical/urethral) which caused by Neisseria gonorrhoeae (penicilinase-and non penicilinase-producing strains).
Contraindications
Patients with a history of shock or hypersensitivity caused by any ingredient of this product.
Precautions
1. General Precautions: Careful inquiry about any form of hypersensitivity should be made, since reactions such as shock may occur.
2. This product should not be administered to the following patients as a general rule. If necessary, however, it can be administered with care.
Patients with a past history of hypersensitivity to any of ingredients in this product or any other cephem antibiotics.
3. Careful Administration:
a. Patients with a history of hypersensitivity to penicilins.
b. Patients with a personal or familial history of some form of allergy such as bronchial asthma, rash, urticaria.
c. Patients with serious renal functions disorder.
d. Patients with poor oral nutrition, patients receiving parenteral nutrition, elderly patients or patients in a debilitated state; Careful observation is essential
in these patients as vitamin K deficiency symptoms may develop.
4. Use during Pregnancy
Safety during pregnancy has not been established. This product should be administered to pregnant patients or women suspected of being pregnant, only if the expected therapeutic benefit is thought to outweigh any possible risk.
5. Use in Nursing Mother
It is not known whether Cefixime is excreted in human milk. Consideration should be given to discontinuing nursing temporarily during treatment with this drug.
6. Use in Newborns or Prematures
Efficacy and safety in children aged less than 6 months have not been established (including in newborn and prematures).
Adverse Reactions
1. Shock
Adequate caution in administration should be used as shock symptoms may rarely S, h3"y'e d !lgnS 0r sVmPtoms s"ch as feeling unwell, oral cavity discomfort, strrctor dizziness abnormal urge to defecate, tinnitus or diaphoresis occur, this product must be discontinued immediately.
2. Hypersensitivity
If signs of hypersensitivity reactions such as rash, urticaria, erythema, pruritus or Le taken ' be discontinued and appropriate measures should
3. Hematologic
Granulocytopenia or eosinophilia infrequently may occur. Rarely thrombocytopenia SnL S ! Pr°dUCti?h0uld be disc°"tinued if any of these abnormalities is found. It has been reported that hemolytic anemia has occurred with other oephems.
4. Hepatic
Infrequently an increase in GOT, GPT or alkaline phosphatase may occur.
5. Renal
Periodic monitoring of renal function is recommended as serious renal impairment
?™?nrfa h£ ,•rena.' lnsufiSency may rareli'occur-lf anV °f »ese abnormalities is found, discontinuation of this product and other appropriate measures should be
6. Digestive
In rare instances a serious colitis, such as pseudomembranous colitis, manifested by blood in stools, may occur. Abdominal pain or frequent diarrhoea requires appropriate measures including prompt withdrawal of this product infrequently vomiting diarrhoea, abdominal pain, stomach discomfort, heartburn or anorexia and rarely nausea, feeling of enlarged abdomen or constipation may occur!
7. Respiratory
In rare instances, interstitial pneumoniae or PIE syndrome, manifested by fever cough, dyspnea, abnormal chest x-ray or eosinophilia, may occur. If any such' symptoms occur this product should be immediately discontinued and appropriate measures such as giving adrenocortical hormones should be taken.
8. Alteration in bacterial flora
Rarely stomatitis or candidiasis may occur.
9 Vitamin deficiencies
Rarely vitamin K deficiencies (such as hypothrombinemia or bleeding tendencies) ma rT 9r°JP deflclsncles (such as Qlossitis, stomatitis, anorexia or neuritis)
10. Others
• Rarely headache or dizziness may occur.
. In studies where infants rats were given 1.000 mg/kg/day orally, a reduced spermatogenesis was reported. '
11. Influences on laboratory values
a. False-positive results may occur with urine sugar tests using Benedict's solution Testa lS S° and C"niteSt' Fa'Se positives nave not been ^Ported with
b. A positive direct Coombs test may occur.
Dosage and Administration
' weLSWnnt°^le,h 5° T°° mg and tablet 200 m9: For adults and children weighing > 30 kg, he usual recommended daily dose is 50-100 mg (potency) of cefixime given orally twice daily. Dosage should be adjusted according to the age body weight and condition of the patient. For more severe or intractable infections rS.™ I99 may' '"creased JP t0 200 mg (potency) given twice daily.
■ Cefspan® suspension 100 mg: The usual pediatric daily dose is 1.5 - 3 mg (potency)Ao given orally twice daily. Dosage should be adjusted according to the condition of the
ton ™ fr?„rtm°rewfV8re °r int'ac,able infections, the dosage may be increased up to 6 mg (potency)/kg given orally twice daily . I" children, otitis media should be treated with suspension. Clinical studies of otitis medtewera-oondi^ad with the suspension and the suspension results in higher peak blood levels than the tablet when administered at the same dose Therefore S„™l0n sh°u!d not be substituted in the treatment of otitis media!
• Typhoid fever in children: 10 -15 mg/kg/day for 2 weeks
' th.'^ Withrimpaired r9nral ,unction re<'uire modification of dosage depending on he degree of impairment. The recommended dosage is 75% of the standard dosage n»«;n( 9 VJ 1" creatlnine clearance is between 21 and 60 ml/min or for patients on renal hemodialysis, and 50% of the standard dosage (i.e. 200 mg daily)
^huif, me dearan?e is lsss than 20 ml/min or for patients on continuous ambulatory peritoneal dialysis.
• In case of over dosage:
Sfrl™ 'aVa?e m^,be indicated; otherwise, no specific antidote exists. Cefixime is diatyS '" S'gnlflCant 1uantlties from the circulation by hemodialysis or peritoneal
• For uncomplicated cervical/urethral gonorrhoeae, a single dose of 400 mg is recommended. M
Presentation
naS!,Smg: Box of 3 strips x 10 capsules Reg. No. DKL9211616501A1
S Inn m° : n™ ° ? S'ripS X 1 ° CapSUleS Re9- N0- DKL 9211616501B1
Filcotab 200 mg : Box of 1 strip x 10 tablets Reg. No. DKL 0311636517A1
Dry Syrup : Bottle of 30 ml Reg. No. DKL9211616738A1
nrlZC°"fitM°?' *e s,u„sPension maV be kePt 'or 7 days either at room temperature SlSaSvC S'9nifiCant '0SS °' P°,enCy- Keep «gh«V ciosedPDiscard Add 20 ml of water, shake for 60 seconds m
Q Capsules : Store below 25°C. Dry Syrup and Tablet: Store below 30°C.
HARUS DENGAN RESEP DOKTER On medical prescription only.
TROLIT
TROLIT
Uraian :
Trolit digunakan untuk membantu mengembalikan cairan tubuh dan elektrolit yang hilang pada kasus dimana diperlukan rehidrasi.
Kegunaan:
Membantu memperbaiki daya tahan tubuh serta membantu mengembalikan cairan tubuh dan elektrolit yang hilang.
Petunjuk Pemakaian :
Larutkan 1 sachet Trolit dalam 200 ml air, aduk dan siap diminum.
Maksimal 6 sachet per hari.
Kemasan :
Serbuk dalam sachet.
Tiap dus mengandung 6 sachet Trolit.
POM SD. 041 216 261
Simpan pada suhu kamar (maks. 30°C).
Suplemen Makanan.
Uraian :
Trolit digunakan untuk membantu mengembalikan cairan tubuh dan elektrolit yang hilang pada kasus dimana diperlukan rehidrasi.
Kegunaan:
Membantu memperbaiki daya tahan tubuh serta membantu mengembalikan cairan tubuh dan elektrolit yang hilang.
Petunjuk Pemakaian :
Larutkan 1 sachet Trolit dalam 200 ml air, aduk dan siap diminum.
Maksimal 6 sachet per hari.
Kemasan :
Serbuk dalam sachet.
Tiap dus mengandung 6 sachet Trolit.
POM SD. 041 216 261
Simpan pada suhu kamar (maks. 30°C).
Suplemen Makanan.
VOMITAS
VOMITAS
GOLONGAN GENERIK
Domperidone.
INDIKASI
Pengobatan mual dan muntah akut termasuk yang disebabkan oleh pengobatan yang menggunakan Levodopa dan Bromokriptin selama lebih dari 12 minggu, dispepsia fungsional.
KONTRA INDIKASI
Prolaktinoma, terdapat perdarahan lambung-usus, perlubangan atau penyumbatan mekanikal.
PERHATIAN
Hamil, menyusui, pengobatan jangka panjang.
Disfungsi hati atau ginjal, bayi berusia kurang dari 1 tahun.
Interaksi obat :
- Aksi dihambat oleh zat antimuskarinik dan analgetik opioid.
- Menurunkan efek Bromokriptin.
- Bioavailabilitas dikurangi oleh antasida.
EFEK SAMPING
Jarang : sedasi, reaksi ektrapiramidal, galaktore (mengalirnya air susu dari payudara secara spontan dan deras di antara waktu menyusui atau setelah anak disapih), ginekomastia (pembesaran buah dada laki-laki menyerupai buah dada perempuan), mulut kering, sakit kepala, diare, ruam, haus, kecemasan, gatal.
KEMASAN
Syrup 5 mL x 60 mL
DOSIS
# Dispepsia fungsional pada orang dewasa : 10-20 mg 3 kali sehari dan pada malam hari.
Lama pengobatan maksimal : 12 minggu.
# Mual dan muntah :
- dewasa : 10-20 mg tiap 4-8 jam.
- anak-anak : 0,2-0,4 mg/kg berat badan/hari dengan jarak pemberian 4-8 jam.
GOLONGAN GENERIK
Domperidone.
INDIKASI
Pengobatan mual dan muntah akut termasuk yang disebabkan oleh pengobatan yang menggunakan Levodopa dan Bromokriptin selama lebih dari 12 minggu, dispepsia fungsional.
KONTRA INDIKASI
Prolaktinoma, terdapat perdarahan lambung-usus, perlubangan atau penyumbatan mekanikal.
PERHATIAN
Hamil, menyusui, pengobatan jangka panjang.
Disfungsi hati atau ginjal, bayi berusia kurang dari 1 tahun.
Interaksi obat :
- Aksi dihambat oleh zat antimuskarinik dan analgetik opioid.
- Menurunkan efek Bromokriptin.
- Bioavailabilitas dikurangi oleh antasida.
EFEK SAMPING
Jarang : sedasi, reaksi ektrapiramidal, galaktore (mengalirnya air susu dari payudara secara spontan dan deras di antara waktu menyusui atau setelah anak disapih), ginekomastia (pembesaran buah dada laki-laki menyerupai buah dada perempuan), mulut kering, sakit kepala, diare, ruam, haus, kecemasan, gatal.
KEMASAN
Syrup 5 mL x 60 mL
DOSIS
# Dispepsia fungsional pada orang dewasa : 10-20 mg 3 kali sehari dan pada malam hari.
Lama pengobatan maksimal : 12 minggu.
# Mual dan muntah :
- dewasa : 10-20 mg tiap 4-8 jam.
- anak-anak : 0,2-0,4 mg/kg berat badan/hari dengan jarak pemberian 4-8 jam.
PROFILAS
PROFILAS
GOLONGAN
GENERIK
Ketotifen Hidrogen Fumarat.
INDIKASI
Pengobatan profilaksis jangka panjang dari asma bronkial.
Pencegahan rinitis alergika & dermatitis.
PERHATIAN
# Dapat mengganggu kemampuan mengendarai kendaraan atau mengoperasikan mesin.
# Glaukoma sudut sempit, epilepsi.
# Hamil & menyusui.
# Terapi penghambat mono amin oksidase (MAOI).
Interaksi obat :
- efek sedasi dipertinggi oleh depresan susunan saraf pusat lain.
- efek seperti Atropin terpotensiasi oleh antikolinergik lainnya, antidepresan trisiklis, dan MAOI.
EFEK SAMPING
Mengantuk, pusing, mulut kering.
KEMASAN
Sirup 0,2 mg/mL x 60 mL.
DOSIS
Anak-anak : 2 kali sehari 0,125 mL sirup (0,025 mg)/kg berat badan
GOLONGAN
GENERIK
Ketotifen Hidrogen Fumarat.
INDIKASI
Pengobatan profilaksis jangka panjang dari asma bronkial.
Pencegahan rinitis alergika & dermatitis.
PERHATIAN
# Dapat mengganggu kemampuan mengendarai kendaraan atau mengoperasikan mesin.
# Glaukoma sudut sempit, epilepsi.
# Hamil & menyusui.
# Terapi penghambat mono amin oksidase (MAOI).
Interaksi obat :
- efek sedasi dipertinggi oleh depresan susunan saraf pusat lain.
- efek seperti Atropin terpotensiasi oleh antikolinergik lainnya, antidepresan trisiklis, dan MAOI.
EFEK SAMPING
Mengantuk, pusing, mulut kering.
KEMASAN
Sirup 0,2 mg/mL x 60 mL.
DOSIS
Anak-anak : 2 kali sehari 0,125 mL sirup (0,025 mg)/kg berat badan
DIALAC
DIALAC
GENERIK
Tyndallized lyophilizate Lactobacillus acidophilus 340 mg, niasin 1 mg ; Ca 20 mg ; Zn oksida 1.3 mg ; tiamin HCl 3 mg ; riboflavin 0.3 mg ; piridoksin HCl 0.3 mg ; asam askorbat 25 mg.
INDIKASI
# Untuk mempertahankan fungsi normal usus pada anak-anak & dewasa.
# Membantu meredakan atau mencegah diare.
PERHATIAN
Bersamaan dengan perawatan medis.
KEMASAN
Box 1 g x 20 sachet
DOSIS
Dewasa & anak-anak: 2-4 sachet sehari. Untuk anak-anak: dapat dicampur dengan air atau susu. Dosis dapat ditambah jika diperlukan.
GENERIK
Tyndallized lyophilizate Lactobacillus acidophilus 340 mg, niasin 1 mg ; Ca 20 mg ; Zn oksida 1.3 mg ; tiamin HCl 3 mg ; riboflavin 0.3 mg ; piridoksin HCl 0.3 mg ; asam askorbat 25 mg.
INDIKASI
# Untuk mempertahankan fungsi normal usus pada anak-anak & dewasa.
# Membantu meredakan atau mencegah diare.
PERHATIAN
Bersamaan dengan perawatan medis.
KEMASAN
Box 1 g x 20 sachet
DOSIS
Dewasa & anak-anak: 2-4 sachet sehari. Untuk anak-anak: dapat dicampur dengan air atau susu. Dosis dapat ditambah jika diperlukan.
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